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Leser-Trélat sign : ウィキペディア英語版 | Leser–Trélat sign
The Leser-Trélat sign is the explosive onset of multiple seborrheic keratoses (many pigmented skin lesions),〔(【引用サイトリンク】title=eMedicine - Sign of Leser-Trelat : Article by Robert A Schwartz )〕 often with an inflammatory base. This can be an ominous sign of internal malignancy as part of a paraneoplastic syndrome. In addition to the development of new lesions, preexisting ones frequently increase in size and become symptomatic. ==History== It is named for Edmund Leser and Ulysse Trélat.〔Leser E. Ueber ein die Krebskrankheit beim Menschen haufig begleitendes, noch wenig gekanntes Symptom. Munchener Med Wochenschr. 1901;51:2035-2036.〕 It has been suggested that Leser and Trélat were observing angiomas and not seborrheic keratoses, and so the credit should properly go to Hollander for his 1900 publication.〔(【引用サイトリンク】title=Sign of Leser-Trelat )〕〔Hollander E. V. Beitrage zur Fruhdiagnose des Darmcarcinomas (Hereditatsverhaltnisse und Hautveranderungen. Deutsche Medicinische Wochenschrift. 1900;26:483-485.〕
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